Establishment of a surgically induced cryptorchidism canine recipient model for spermatogonial stem cell transplantation
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چکیده
منابع مشابه
Establishment of a surgically induced cryptorchidism canine recipient model for spermatogonial stem cell transplantation
Transplantation of spermatogonial stem cells (SSCs) in experimental animal models has been used to study germ line stem cell biology and to produce transgenic animals. The species-specific recipient model preparation is important for the characterization of SSCs and the production of offspring. Here, we investigated the effects of surgically induced cryptorchidism in dog as a new recipient mode...
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Spermatogonial stem cell transplantation was first reported by Ralph Brinster's laboratory in 1994. It has proven to be a technological breakthrough in the study of both stem cells and Sertoli cell-germ cell interactions. This technique can be used to transfer testicular stem cells successfully from one animal to another of the same species (referred to as syngeneic transplants) and sometimes t...
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BACKGROUND Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis, and reside within a specific microenvironment in the testes called "niche" which regulates stem cell properties, such as, self-renewal, pluripotency, quiescence and their ability to differentiate. METHODOLOGY/PRINCIPAL FINDINGS Here, we introduce zebrafish as a new model for the study of SSCs in vertebrates. Us...
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Spermatogonial stem cell transfer has been studied in various species and suggested potential for success. Bull, stallion, donkey, mule, boar, dog and cat testicles were examined using various injection techniques to determine distribution patterns of injected material most favorable for stem cell transfer. Spermatogonial stem cells were recovered from freshly harvested stallion testicles using...
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ژورنال
عنوان ژورنال: Laboratory Animal Research
سال: 2016
ISSN: 1738-6055,2233-7660
DOI: 10.5625/lar.2016.32.4.257